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KMID : 0377220010260010049
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Medical Journal of Chosun Univercity
2001 Volume.26 No. 1 p.49 ~ p.57
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Antimicrobial resistance of Staphylococcus aureus according to the isolated sites
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Lim Yong
Lee Kang-Kil
Shin Sung-Heui
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Abstract
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Objectives: Staphylococcus aureus showing multi-drug resistance is one of the major human pathogens causing nosocomial infection. The aim of this study is to investigate the difference of antimicrobial resistance according to the isolation sites and to offer the latest information of antimicrobial chemotherapy and reappraisal.
Materials and Methods: We isolated and identified seventy stains of S. aureus from community hospitals and the isolated strains were classified according to the isolation sites. Disk diffusion test was used for the determination of antibiotic resistance.
Results: The obtained results were as the follows. (1) Methicillin-resistant S. aureus was 54.3% of the total seventy strains. 92.9% were susceptible against sulphamethoxazole and trimethoprim and 100% against vancomycin. (2) When the total isolates were divided into the three groups including the isolates from patients (56 strains), those from doctors and nurses (7 strains) and those from a hospital environment (7 strains), there was a slight, but not significant difference in the resistance ratio against the tested antimicrobial agents. (3) There was a striking difference in the resistance ratio between the isolates obtained from the outpatient department (OPD, 16 strains) and those from the hospitalized patients (40 strains). Isolates obtained from OPD showed a higher susceptibility than those from the hospitalized patients (p<0.05) and all the isolates obtained from OPD proved MSSA (methicillin-susceptible S. aureus).
Conclusion: Taken together, these findings suggest that there is an intimate circuit for bacterial transmission among the three groups. The higher susceptibility in the isolates from OPD suggests that they may be less frequently exposed to antimicrobial agents and originated from either a natural environment or the nares of normal persons but not from the hospital environments.
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KEYWORD
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Staphylococcus, Antimicrobial resistance, MRSA
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